Awarded Trial: 07TGF-1097
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, CGI, Simpson-Angus, CDSS, GAF, QLS, ESRS
Bexarotene, a synthetic retinoid used to treat some cancers, was used as an adjunct to treat schizophrenia. 90 patients were given bexarotene 75 mg/d. or placebo for 6 weeks. 79 completed the study. Patients receiving bexarotene had a significant improvmenet on the PANSS positive subscale (p,.001) and on the Global Assessment of Functioning (p,.001). This thus confirms a previous smaller study.
Lerner V, Miodownik C, Gibel A, Sirota P, Bush I, Elliot H, Benatov R, Ritsner MS. The Retinoid X Receptor Agonist Bexarotene Relieves Positive Symptoms of Schizophrenia: A 6-Week, Randomized, Double-Blind, Placebo-Controlled Multicenter Trial. J Clin Psychiatry. 2013 Dec;74(12):1224-32.
Ben Gurion University of the Negev
str. HaTsadik MiYerushalaim, 2
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