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Awarded Trial: 04T-583
Grant ID
04T-583
Illness
Schizophrenia
Primary Drug/Intervention
Minocycline
Primary Dosage
200 mg/day
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Chaudhry
Sample Size
80
Duration of Study Period for Each Subject
1 year
Outcome Measurements
PANSS, cognitive battery
Results
Fifty-one patients were randomized to receive minocycline or placebo adjunctively to treatment as usual. There were no significant differences between groups on PANSS scores or on cognitive outcome measures.
Publication
Chaudhry IB, Hallak J, Husain N, Minhas F, Stirling J, Richardson P, Dursun S, Dunn G, Deakin B. Minocycline benefits negative symptoms in early schizophrenia; a randomised double-blind placebo-controlled clinical trial in patients on standard treatment. J Psychopharmacol. 2012 Sep;26(9):1185-93
Link
http://www.ncbi.nlm.nih.gov/pubmed/22526685
PI Name
Imran Chaudhry
Degree
MD
Center
Neurosciences and Psychiatry Unit
Institution
University of Manchester
Address
G907, Stopford Building, Oxford Road
City or Town
Manchester
State or Province
N/A
Zip or Postal Code
M13 9PT
Country
United Kingdom
Email Address
ibchaudhry@btinternet.com