Awarded Trial: 04T-580
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, CGI-S, TESS, ESRS
One hundred twenty one patients with treatment resistant schizophrenia were given ondansetron or placebo adjunctively to haloperidol (4-20 mg/day). Ondansetron treatment was associated with significant improvement in PANSS total, negative symptoms and general symptoms. Ondansetron-treated patients also had fewer extrapyramidal side effects.
Zhang ZJ, Kang WH, Li Q, Wang XY, Yao SM, Ma AQ. Beneficial effects of ondansetron as an adjunct to haloperidol for chronic, treatment-resistant schizophrenia: A double-blind, randomized, placebo-controlled study. Schizophr Res. 2006 Dec;88(1-3):102-10. Epub 2006 Sep 7.
Department of Psychiatry
The First Hospital, Xi'an Jiaotong University College of Medicine
1 Jian Kang Road
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