Awarded Trial: 03T-356
300 mg b.i.d.
Secondary Drug Intervention
Duration of Study Period for Each Subject
One-hundred and sixty patients were randomized, and 139 patients completed the trial. There was a significant improvement in YMRS scores for patients treated with allopurinol, but not for those treated with dipyridamole. Eighty four percent of patients treated with allopurinol were considered to be responders (>50% improvement in YMRS) compared to 57% of patients treated with dipyridamole and 70% of patients given placebo.
Machado-Vieira R, Soares JC, Lara DR, Luckenbaugh DA, Busnello JV, Marca G, Cunha A, Souza DO, Zarate CA Jr, Kapczinski F. A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. J Clin Psychiatry. 2008 Aug;69(8):1237-45.
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