Awarded Trial: 03T-315
Ethyl Eicosapentanoic Acid
Secondary Drug Intervention
Duration of Study Period for Each Subject
PACE criteria for ARMS, PANSS, MADRS, GAF, Conversion to psychosis
Eighty one patients, aged 13 to 24, who were considered to be at high risk for psychosis were randomized. High risk patients met operationalized definitions for "attenuated psychotic symptoms", "transient psychosis", or "genetic risk plus decrease in functioning". The cumulative rate of conversion to psychosis at 3 months was 2.4% for the omega-3 group and 20.0% for the placebo group. This difference seemed to be maintained at 6 and 12 months of follow-up.
Amminger GP, Schafer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM, Mackinnon A, McGorry PD, Berger GE. Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 2010; 67(2):146-154. Amminger GP, McGorry PD. Update on ω-3 polyunsaturated fatty acids in early-stage psychotic disorders. Neuropsychopharmacology. 2012 Jan;37(1):309-10.
Department of Child and Adolescent Neuro-Psychiatry
University of Vienna
Waehringer Guertel 18-20
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