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Awarded Trial: 02T-228

Grant ID

02T-228

Illness

BP Depression

Primary Drug/Intervention

Phototherapy

Primary Dosage

50 lux red light for 2 weeks, followed by 7,000 lux light for 2-week epochs of 15, 30, and 45 min

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Wisner

Sample Size

30

Duration of Study Period for Each Subject

26 weeks

Outcome Measurements

Hamilton Depression Rating Scale--Atypical Depression symptoms version

Results

Eleven patients completed the trial. Three of four patients who received morning light treatment experienced a switch to manic or mixed states. Five of seven subjects receiving midday light had a significant improvement in depression. The optimal response was observed at 45 or 60 minutes of therapy.

Publication

Sit D, Wisner KL, Hanusa BH, Stull S, Terman M. Light therapy for bipolar disorder: a case series in women. Bipolar Disord. 2007 Dec;9(8):918-27.

Link

http://www.ncbi.nlm.nih.gov/pubmed/18076544

PI Name

Katherine Wisner

Degree

MD

Center

Women's Behavioral Health CARE

Institution

Western Psychiatric Institute and Clinic

Address

3811 O'Hara Street

City or Town

Pittsburgh

State or Province

PA

Zip or Postal Code

15213

Country

USA

Email Address

wisnerkl@upmc.edu