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Awarded Trial: 02T-170

Grant ID

02T-170

Illness

Major Depression

Primary Drug/Intervention

Triiodothyronine

Primary Dosage

40-50 mcg

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

Sertraline

Other Dosage

100mg/d

Status

Completed

Investigator

Lerer

Sample Size

124

Duration of Study Period for Each Subject

8 weeks

Outcome Measurements

CGI, HAM-D, HAM-A, BPRS, Visual Analogue Scale

Results

One hundred twenty-four patients were randomized to treatment and 77 completed 8 weeks of treatment. Patients receiving T3 were more likely to achieve a response (37%) than those receiving placebo (25%) and were also more likely to achieve remission (34% vs. 21%).

Publication

Cooper-Kazaz R, Apter JT, Cohen R, Karagichev L, Muhammed-Moussa S, Grupper D, Drori T, Newman ME, Sackeim HA, Glaser B, Lerer B. Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial. Arch Gen Psychiatry. 2007 Jun;64(6):679-88.

Link

http://www.ncbi.nlm.nih.gov/pubmed/17548749

PI Name

Bernard Lerer

Degree

MD

Center

Biological Psychiatry Laboratory, Department of Psychiatry

Institution

Hadassah-Hebrew University Medical Center

Address

Ein Karem

City or Town

Jerusalem

State or Province

N/A

Zip or Postal Code

91120

Country

Israel

Email Address

lerer@cc.huji.ac.il