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Awarded Trial: 02T-162

Grant ID

02T-162

Illness

Bipolar Disorder

Primary Drug/Intervention

Tamoxifen

Primary Dosage

80mg

Secondary Drug Intervention

N/A

Secondary Dosage

N/A

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Yildiz-Yesiloglu

Sample Size

50

Duration of Study Period for Each Subject

3 weeks

Outcome Measurements

YMRS

Results

Forty-eight percent of patients in the tamoxifen group experienced a greater than 50% drop in YMRS scores, compared to 5% of patients in the placebo group.

Publication

Yildiz A, Guleryuz S, Ankerst DP, Ong├╝r D, Renshaw PF. Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen. Arch Gen Psychiatry. 2008;65:255-263.

Link

http://www.ncbi.nlm.nih.gov/pubmed/18316672

PI Name

Aysegul Yildiz-Yesiloglu

Degree

MD

Center

N/A

Institution

Ozmavikent Konut Yapi Kooperatifi

Address

Saffet Baba Sok, Huzur Mah, No. 27/12

City or Town

Narlidere

State or Province

Izmir

Zip or Postal Code

35320

Country

Turkey

Email Address

agul_yildiz@hotmail.com