Awarded Trial: 01T-420
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, Calgary Depression, extra-pyramidal side effects and akathesia or quality of life scales
Thirty-five subjects were randomized to receive celecoxib 400 mg given adjunctively to antipsychotics or placebo for eight weeks. No differences were found between groups on PANSS, Calgary Depression, extra-pyramidal side effect or quality of life scales. Soluble interleukin-2 receptor levels did not predict response to the drug.
Rapaport MH, Delrahim KK, Bresee CJ, Maddux RE, Ahmadpour O, Dolnak D. Celecoxib augmentation of continuously ill patients with schizophrenia. Biological Psychiatry 57:1594-1596, 2005.
Department of Psychiatry
University of California
8950 Villa la Jolla Drive, C207
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