Awarded Trial: 01T-400
2 g twice per day
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, CGI, Global Assessment of Functioning, AIMS, Simpson-Angus, Barnes Akathisia
There was a significant effect of active drug on CGI, PANSS negative, PANSS general and PANSS total scores. There was also a reduction in alcohol and substance use and akathisia associated with drug treatment.
Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Judd F, Katz F, Katz P, Ording-Jespersen S, Little J, Conus P, Cuenod M, Do KQ, Bush AI. N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial. Biol Psychiatry. 2008 Sep 1;64(5):361-8. doi: 10.1016/j.biopsych.2008.03.004. Epub 2008 Apr 23.
Mental Health Research Institute
University of Melbourne
155 Oak Street
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