Awarded Trial: 01T-047
100 mg b.i.d.
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS, SANS, SAPS, Simpson-Angus, AIMS, Barnes Akathasia Cognitive Battery
In the 29 patients who completed at least three weeks of the trial, amantadine was associated with improvement in visuomotor coordination in male patients at week 3 compared to baseline. Other measures of cognitive function and psychopathology were not significantly changed.
Silver H, Goodman C, Isakov V, Knoll G, Modai I. A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients. Int. Clin. Psychopharmacol. 2005 Nov; 20(6):319-26.
Sha'ar Menashe Mental Health Center
Technion Research and Development Foundation
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