Awarded Trial: 01-055
Secondary Drug Intervention
at least 400mg/day
Duration of Study Period for Each Subject
PANSS, ESRS, BAS, CGI, Cognitive Battery
There was no statistically significant difference between risperidone and placebo for patients who had a poor response to clozapine alone with regard to symptom ratings. There were no differences between groups with regard to movement disorder side effects.
Honer WG, Thornton AE, Chen EY, Chan RC, Wong JO, Bergmann A, Falkai P, Pomarol-Clotet E, McKenna PJ, Stip E, Williams R, MacEwan GW, Wasan K, Procyshyn R; Clozapine and Risperidone Enhancement (CARE) Study Group. Clozapine Alone versus Clozapine and Risperidone with Refractory Schizophrenia. N Engl J Med. 2006 Feb 2;354(5):472-82.
Centre for Complex Disorders, Jack Bell Chair in Schizophrenia
University of British Columbia
Vancouver General Hospital Research Pavilion, #211 - 828 West 10th Ave
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