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Awarded Trial: 00-310

Grant ID

00-310

Illness

Bipolar Disorder

Primary Drug/Intervention

Tamoxifen

Primary Dosage

40 mg

Secondary Drug Intervention

Progesterone

Secondary Dosage

20 mg

Other Drug/Intervention

N/A

Other Dosage

N/A

Status

Completed

Investigator

Kulkarni

Sample Size

21

Duration of Study Period for Each Subject

4 weeks

Outcome Measurements

CARS-M, PANSS, MADRS, AIMS

Results

6 women received tamoxifen and 4 women received progesterone. Patients receiving tamoxifen made a better, faster recovery than those receiving progesterone or placebo. Adequate statistical interpretation of the data could not be achieved due to small sample size.

Publication

Psychoneuroendocrinology. 2006 May;31(4):543-7. Epub 2005 Dec 13. A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder. Kulkarni J1, Garland KA, Scaffidi A, Headey B, Anderson R, de Castella A, Fitzgerald P, Davis SR.

Link

http://www.ncbi.nlm.nih.gov/pubmed/16356651

PI Name

Jayashri Kulkarni

Degree

PhD

Center

Alfred Psychiatry Research Center

Institution

The Alfred Hospital

Address

Level 1, Old Baker Building, P.O. Box 315

City or Town

Prahran

State or Province

Victoria

Zip or Postal Code

3181

Country

Australia

Email Address

jayashri.kulkarni@med.monash.edu.au