Awarded Trial: 00-209
up to 200 mg
Secondary Drug Intervention
Duration of Study Period for Each Subject
PANSS-total, PANSS-positive, PANSS-negative, CGI
A 12 week, placebo controlled pilot trial of pramipexole augmentation of antipsychotic treatment was conducted in 24 patients with schizophrenia or schizoaffective disorder. Pramipexole treated patients had significantly greater changes in PANSS-total and PANSS-positive subscale scores but not PANSS-negative subscale scores. Pramipexole was considered to be well tolerated.
Eur Neuropsychopharmacol. 2012 Jun;22(6):415-8. doi: 10.1016/j.euroneuro.2011.10.002. Epub 2011 Dec 7. Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment. Kelleher JP1, Centorrino F, Huxley NA, Bates JA, Drake JK, Egli S, Baldessarini RJ.
Department of Research
St. Vincent's Hospital Westchester
275 North Street
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