Awarded Trial: 00-032
Topiramate + Olanzapine
Secondary Drug Intervention
Duration of Study Period for Each Subject
In an eight week open label study, 16 youths aged 5 to 18 years received treatment with olanzapine (2.5-20 mg per day) and 18 youths received olanzapine plus topiramate (25-100 mg per day). All patients had mania or mixed mania. Both groups showed improvement in symptoms of mania, but there was no significant benefit of adjunctive topiramate on YMRS scores. Patients who received topiramate gained less weight than those who did not, but the difference did not reach statistical significance.
Wozniak J, Mick E, Waxmonsky J, Kotarski M, Hantsoo L, Biederman J. Comparison of open-label, 8-week trials of olanzapine monotherapy and topiramate augmentation of olanzapine for the treatment of pediatric bipolar disorder. J Child Adolesc Psychopharmacol. 2009 Oct;19(5):539-45.
Massachusetts General Hospital
Massachusetts General Hospital, ACC 725
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